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James Cranley
BM BCh, MA, MRCP
I am a clinician-scientist interested in the intersection of cell biology, genomics, and inherited cardiac disease. My clinical subspecialty is electrophysiology and inherited cardiac conditions. My PhD was in Sarah Teichmann’s lab at the Sanger Institute where I used single-cell and spatial genomics to create a cell atlas of the human heart.
Education
Sanger Institute (Cambridge University)
PhD (thesis submitted March 2024)
Cambridge, UK
2024 - 2021
Cambridge University
PG Certificate in Medical Education
Cambridge, UK
2019
Academic Clinical Fellowship in Cardiology
National Instiute for Health Research (NIHR)
Cambridge, UK
2018 - 2015
Membership of the Royal College of Physicians
Royal College of Physicians
London, UK
2016
Oxford Medical School
BM BCh (Distinction), Intercalated BSc (1st class)
Oxford, UK
2013 - 2007
Eton College
7 ’A’s: Maths, Further Maths, Chemistry, Biology, French, Latin, Greek
Windsor, UK
2007 - 2002
Research Experience
Wellcome Trust PhD Fellowship
Single-cell and spatial transcriptomic analysis of the adult and developing human heart. Supervisor: Professor Sarah Teichmann (Sanger Institute)
N/A
2024 - 2021
NIHR Academic Clinical Fellowship
- 2018: Genome-wide association study into ECG trait using UK Biobank data. Supervisor: Professor Patsy Munroe (QMUL).
- 2017: Introduction to zebrafish as a model for cardiovascular disease. Supervisor: Professor Calum MacRae (Harvard University).
- 2016: A murine model of metabolic syndrome. Murine electrophysiology lab. Supervisor: Professor Chris Huang (Cambridge University).
N/A
2018 - 2016
Bachelor of Science
Investigating the role of the neuropeptide Galanin in cardiac autonomics. Supervisor: Professor Neil Herring (Oxford University).
N/A
2013
Publications
Spatially resolved multiomics of human cardiac niches
Nature
Kazumasa Kanemaru*, James Cranley*, Daniele Muraro, Antonio M. A. Miranda, Siew Yen Ho, Anna Wilbrey-Clark, Jan Patrick Pett, Krzysztof Polanski, Laura Richardson, Monika Litvinukova, Natsuhiko Kumasaka, Yue Qin, Zuzanna Jablonska, Claudia I. Semprich, Lukas Mach, Monika Dabrowska, Nathan Richoz, Liam Bolt, Lira Mamanova, Rakeshlal Kapuge, Sam N. Barnett, Shani Perera, Carlos Talavera-López, Ilaria Mulas, Krishnaa T. Mahbubani, Liz Tuck, Lu Wang, Margaret M. Huang, Martin Prete, Sophie Pritchard, John Dark, Kourosh Saeb-Parsy, Minal Patel, Menna R. Clatworthy, Norbert Hübner, Rasheda A. Chowdhury, Michela Noseda, Sarah A. Teichmann
N/A
2023
Multiomics reveal developmental dynamics of the human heart
James Cranley*, Kanemaru K*, Bayraktar S*, KnightSchrijver V, Pett J, Polanski K, Dabrowska M, Mulas I, Richardson L, Semprich C, Kapuge R, Perera S, He X, Ho S, Yayon N, Tuck L, Roberts K, Palmer J, Davaapil H, Gambardella L, Patel M, Tyser R, Sinha S, Teichmann SA
N/A
2023
High-resolution atlas of the developing human heart and the great vessels
Bayraktar S*, James Cranley*, Kanemaru K, KnightSchrijver V, Colzani M, Davaapil H, Lee J, Polanski K, Richardson L, Semprich C, Kapuge R, Dabrowska M, Mulas I, Perera S, Patel M, Ho S, He X, Tyser R, Gambardella L, Teichmann SA, Sinha S.
N/A
2023
CellPhoneDB v5: inferring cell-cell communication from single-cell multiomics data
Under review at Nature Protocols
Kevin Troulé*, Robert Petryszak, Martin Prete, James Cranley, Alicia Harasty Zewen Kelvin Tuong, Sarah A Teichmann, Luz Garcia-Alonso, Roser Vento-Tormo
N/A
2023
Multidimensional Analysis of the Adult Human Heart in Health and Disease using Hierarchical Phase-Contrast Tomography (HiP-CT)
J. Brunet*, A. C. Cook, C. L. Walsh, James Cranley, P. Tafforeau, K. Engel, C. Berruyer, E. Burke O’Leary, A. Bellier, R. Torii, C. Werlein, D. D. Jonigk, M. Ackermann, K. Dollman, P. D. Lee
N/A
2023
A single-cell comparison of adult and fetal human epicardium defines the age-associated changes in epicardial activity
Nature Cardiovascular Research
Vincent R. Knight-Schrijver*, Hongorzul Davaapil, Semih Bayraktar, Alexander D. B. Ross, Kazumasa Kanemaru, James Cranley, Monika Dabrowska, Minal Patel, Krzysztof Polanski, Xiaoling He, Ludovic Vallier, Sarah Teichmann, Laure Gambardella, Sanjay Sinha
N/A
2022
Single-cell transcriptomics for the assessment of cardiac disease
Nature Reviews Cardiology
Antonio M. A. Miranda*, Vaibhao Janbandhu, Henrike Maatz, Kazumasa Kanemaru, James Cranley, Sarah A. Teichmann, Norbert Hübner, Michael D. Schneider, Richard P. Harvey, Michela Noseda
N/A
2022
Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies
Science
Daniel Reichart*, Eric L. Lindberg*, Henrike Maatz, Antonio M. A. Miranda, Anissa Viveiros, Nikolay Shvetsov, Anna Gärtner, Emily R. Nadelmann, Michael Lee, Kazumasa Kanemaru, Jorge Ruiz-Orera, Viktoria Strohmenger, Daniel M. DeLaughter, Giannino Patone, Hao Zhang, Andrew Woehler, Christoph Lippert, Yuri Kim, Eleonora Adami, Joshua M. Gorham, Sam N. Barnett, Kemar Brown, Rachel J. Buchan, Rasheda A. Chowdhury, Chrystalla Constantinou, James Cranley, Leanne E. Felkin, Henrik Fox, Ahla Ghauri, Jan Gummert, Masatoshi Kanda, Ruoyan Li, Lukas Mach, Barbara McDonough, Sara Samari, Farnoush Shahriaran, Clarence Yapp, Caroline Stanasiuk, Pantazis I. Theotokis, Fabian J. Theis, Antoon van den Bogaerdt, Hiroko Wakimoto, James S. Ware, Catherine L. Worth, Paul J. R. Barton, Young-Ae Lee, Sarah A. Teichmann, Hendrik Milting, Michela Noseda, Gavin Y. Oudit, Matthias Heinig, Jonathan G. Seidman, Norbert Hubner, Christine E. Seidman
N/A
2022
Impact of COVID-19 pandemic on cardiac rhythm management services: Views from the United Kingdom.
Heart rhythm O2
Wern Yew Ding*, James Cranley, David Begley, Archana Rao, Richard L. Snowdon, Greg Mellor, Dhiraj Gupta
N/A
2022
Identifying predictive risk factors for permanent pacemaker implantation up to 30 days post-TAVI
European Heart Journal
J Li*, A Christodoulidou, James Cranley, F Ara, Charis Costopoulos, P Costanzo, M Osullivan, W Davies, C Densem, C A Martin
N/A
2021
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.
Nature communications
Ioanna Ntalla*, Lu-Chen Weng, James H. Cartwright, Amelia Weber Hall, Gardar Sveinbjornsson, Nathan R. Tucker, Seung Hoan Choi, Mark D. Chaffin, Carolina Roselli, Michael R. Barnes, Borbala Mifsud, Helen R. Warren, Caroline Hayward, Jonathan Marten, James Cranley, Pier D. Lambiase, Michele Orini, Julia Ramirez, Stefan Van Duijvenboden, David O. Arnar, Daniel F. Gudbjartsson, Hilma Holm, Patrick Sulem, Gudmar Thorleifsson, Rosa B. Thorolfsdottir, Unnur Thorsteinsdottir, Emelia J. Benjamin, Andrew Tinker, Kari Stefansson, Patrick T. Ellinor, Yalda Jamshidi, Steven A. Lubitz, Patricia B. Munroe
N/A
2020
Pulsed Levosimendan in advanced heart failure due to congenital heart disease: a case series.
European heart journal. Case reports
James Cranley*, Antonia Hardiman, Leisa J Freeman
N/A
2020
Clinical outcomes of bioresorbable vascular scaffolds implanted with routine versus selective optical coherence tomography guidance: results from a single-centre experience.
EuroIntervention
Vincent Floré*, Adam J. Brown, Joel P. Giblett, Kevin Liou, James Cranley, Stephen P. Hoole, Nick E.J. West
N/A
2019
Catastrophic antiphospholipid syndrome causing ST-segment elevation myocardial infarction with non-obstructive coronary arteries.
BMJ case reports
James Cranley*, Unni Krishnan, Katharine Tweed, Rudolf Martin Duehmke
N/A
2019
Regulatory and occupational considerations in cardiology
Medicine
James Cranley*, Catriona Bhagra
N/A
2018
Ventricular pro-arrhythmic phenotype, arrhythmic substrate, ageing and mitochondrial dysfunction in peroxisome proliferator activated receptor-γ coactivator-1β deficient (Pgc-1β-/-) murine hearts.
Mechanisms of ageing and development
Shiraz Ahmad*, Haseeb Valli, Karan R. Chadda, James Cranley, Kamalan Jeevaratnam, Christopher L.-H. Huang
N/A
2018
A New Approach to an Old Problem: One Brave Idea.
Circulation research
James Cranley*, Calum A. MacRae
N/A
2018
TCT-405 Optical coherence tomography-guided optimal bioresorbable vascular scaffold implantation informs subsequent implantation without intravascular imaging: further evidence for a ‘learning curve’?
Journal of the American College of Cardiology
Vincent Floré*, Adam Brown, James Cranley, Joel Giblett, Stephen Hoole, Nick West
N/A
2016
Haemodynamic lesion significance is associated with high plaque burden but not with vulnerable plaque composition
Journal of the American College of Cardiology
Adam J. Brown*, Unni Krishnan, Joel Giblett, James Cranley, Martin Bennett, Nicholas West, Stephen Hoole
N/A
2016
Long-term follow-up of patients undergoing free tissue transfer to the lower limb following trauma
European Journal of Plastic Surgery
Dipender Gill*, David J. Bruce, Mark J. Ponsford, James Cranley, Timothy E. Goodacre
N/A
2013
The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: implications for neural control of cardiac excitability.
Journal of molecular and cellular cardiology
Neil Herring*, James Cranley, Michael N. Lokale, Dan Li, Julia Shanks, Eric N. Alston, Beatrice M. Girard, Emma Carter, Rodney L. Parsons, Beth A. Habecker, David J. Paterson
N/A
2011
Galanin reduces cardiac vagal acetylcholine release and bradycardia via a GalR1, protein kinase C dependent pathway
The FASEB Journal
Neil Herring*, James Cranley, Michael N Lokale, Beth Habecker, David J Paterson
N/A
2010
Presentations and Posters
Oxford Nanopore Symposium
Presentation: “What you’re missing matters, integrating short and long read RNAseq”
Oxford, UK
Feb. 2024
SpatialBiology 2023
Spatial Transcriptomics in Human Cell Atlasing
Online
2023
European Society of Cardiology Congress
Poster: “A spatially-resolved multiomic cell atlas reveals gene regulatory networks underlying cell specification in the developing human”
Amsterdam, NL
Aug. 2023
Human Cell Atlas General Meeting
Poster: “A spatially-resolved multiomic atlas of human cardiac development”
Toronto, Canada
Jul. 2023
Royal Society, Hooke Symposium
Presentation: “The adult and developing heart, one cell at a time”
London, UK
Apr. 2023
British Heart Foundation Symposium
Presentation on single-cell atlasing of the heart
Cambridge, UK
Jun. 2022
Cambridge Alumni Festival
Particpated in a public engagement event “The Hopes and Fears Lab” explaining genomic sciences to a lay audience
Cambridge, UK
Sep. 2022
International Conference of Genomics
‘KCNQ1 variants and JLNS, genotype-phenotype correlations’
York, UK
Dec 2019
Heart Rhythm Congress
‘A novel variant causing JLNS, but not LQT1’
Birmingham, UK
Oct. 2019
British Society of Cardiac Imaging
‘Localised effusive-constrictive pericarditis - a late complication of PCI’
Cambridge, UK
May. 2019
Society for Cardiovascular Interventions and Angiography (SCAI)
Risk factors for haematoma development post cardiac catheterisation.
San Diego, USA
May. 2014
Association of Surgeons of Great Britain and Northern Ireland (ASGBI)
‘Appendicitis in women of child-bearing age: the diagnostic process in a busy London teaching hospital’
Glasgow, UK
Jun. 2014
Teaching Experience
BJCA Trainee Representative to BHRS
Committe role representing electrophysiology trainees nationally.
N/A
current - 2022
Adult Life Support Instructor
Registered provider and instructor
N/A
current - 2020
Cardiology Webinars
Organised and recorded a series of educational webinars for cardiology trainees, now hosted at BJCA.tv
N/A
2021 - 2020
Trainee Representative for East of England
Designed and delivered training days, created website.
N/A
2020 - 2017
Preclinical (physiology) and clinical supervisor
Gonville & Caius College, Cambridge
N/A
2017 - 2016
Harefield Medical Student Teaching Programme
Organised a fortnightly schedule for rotating medical students. Taught regularly.
N/A
2015 - 2014
ECG Course - Oxford Revision Courses
Oxford Medical School
N/A
2015
Courses, Qualifications and Awards
Sanger - Core and Further Biostatistics Courses
N/A
N/A
April 2021
Sanger - Reproducible research course (intro to Git)
N/A
N/A
April 2021
Sanger - Primers for Pre-docs
N/A
N/A
Jan 2021
Cardiac MRI Level 1 Course (KCH)
N/A
N/A
May 2019
British Society of Echocardiography Level 1
N/A
N/A
April 2019
Advanced Life Support Instructor
N/A
N/A
2019
ALS instructor course (QMS, Nottingham)
N/A
N/A
October 2018
National Pacemaker course Pacemaker programming and interrogation (Imperial College)
N/A
N/A
Sept 2016
National Pacemaker course Pacemaker programming and interrogation (Imperial College, Sept 2016) FICE Course Focused Echocardiography for critically ill patients (Reading Hospital)
N/A
N/A
June 2016
MRCP PACES
N/A
N/A
February 2016
IMPACT Course (Arrowe Park Hospital, Liverpool)
N/A
N/A
October 2015
MRCP Part II
N/A
N/A
March 2015
MRCP Part I
N/A
N/A
September 2014
Advanced Life Support Provider
N/A
N/A
June 2013
Clinical Experience
Specialty Training, Cardiology (EP and ICC)
N/A
East of England deanery
Dec 2020 - 2017
- ST6: Royal Papworth Hospital (OOPR Dec 2020)
- ST5: Norfolk & Norwich Hospital
- ST3 & ST4: Addenbrooke’s Hospital
Core Medical Training
N/A
East of England deanery
2017 - 2015
- Papworth Hospital: Cardiology
- Hinchingbrooke Hospital: Respiratory
- Addenbrooke’s Hospital: ICU
Foundation Training
N/A
North West Thames deanery
2015 - 2013
- Harefield Hospital: Cardiology
- Hillingdon Hospital: A&E
- Charing Cross Hospital: Acute Medicine
Medical Elective
N/A
Mount Sinai Hospital, New York
2013
- Cardiology Dept, Mount Sinai Hospital. Supervisor: Dr Valentin Fuster
Clinical Audit
CUH Devices Audit 2019 (NICE TA 314)
N/A
N/A
2019
Improving CMT exposure to 2222 QIP, 2017.
N/A
N/A
2017
Hinchingbrooke Hospital Arterial Blood Gas Audit, 2016
N/A
N/A
2016
Harefield Hospital Haematoma post Cardiac Catheterisation Audit, 2014.
N/A
N/A
2014
Charing Cross Acute Mastitis Pathway, 2014.
N/A
N/A
2014
Short & Medium term complications post implanted devices, John Radcliffe Hospital, Oxford, 2012/3.
N/A
N/A
2013